Tissue localization of beta receptors for platelet-derived growth factor and platelet-derived growth factor B chain during wound repair in humans.
نویسندگان
چکیده
منابع مشابه
Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms
Platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta) markedly potentiate tissue repair in vivo. In the present experiments, both in vitro and in vivo responses to PDGF and TGF-beta were tested to identify mechanisms whereby these growth factors might each enhance the wound-healing response. Recombinant human PDGF B-chain homodimers (PDGF-BB) and TGF-beta 1 had id...
متن کاملPlatelet-derived growth factor.
Platelet-derived growth factor was purified from fresh platelets by a large-scale procedure not involving the use of SDS (sodium dodecyl sulphate). The product, 0.5 mg of platelet-derived growth factor, obtained from about 3 x 1013 platelets migrated as a single component in analytical gel electrophoresis in the presence of SDS and showed no inhomogeneity on sedimentation-equilibrium analysis i...
متن کاملRole of platelet-derived growth factor in wound healing.
Platelet-derived growth factor (PDGF) is a potent activator for cells of mesenchymal origin. PDGF stimulates chemotaxis, proliferation, and new gene expression in monocytes-macrophages and fibroblasts in vitro, cell types considered essential for tissue repair. Therefore, we analyzed the influence of exogenously administered recombinant B chain homodimers of PDGF (PDGF-BB) on two experimental t...
متن کاملSignal transduction by the receptors for platelet-derived growth factor.
Platelet-derived growth factor (PDGF) is a connective tissue cell mitogen that originally was purified from human platelets, but recently has been found to be produced by many different cell types (reviewed by Ross et al. 1986; Heldin and Westermark, 1989). The in vivo function of PDGF remains speculative, but the fact that PDGF is released by platelets and by cells involved in the inflammatory...
متن کاملAutocrine stimulation by platelet-derived growth factor-B (PDGF-B)
Autocrine stimulation by platelet-derived growth factor-B (PDGF-B) like factors hasbeenwidely Implicated asan important mechanismin the causeand/or maintenanceof a variety of human tumors. However,normal human cells appear to be resistant to transformation by PDGF-B-like molecules,and a direct demonstrationof the tumor-promoting or tumor maintaining property of a PDGF-B autocrine system is lack...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1993
ISSN: 0021-9738
DOI: 10.1172/jci116429